Beilstein J. Org. Chem.2015,11, 2007–2011, doi:10.3762/bjoc.11.217
substrates were suitable despite being insoluble in water.
Keywords: carbon–boron bond formation; catalytic asymmetric synthesis; chiral copper(II) catalysis; β-hydroxynitriles; Introduction
In recent years, optically active organoboranes have attracted considerable attraction as versatile synthons for
Beilstein J. Org. Chem.2013,9, 2387–2394, doi:10.3762/bjoc.9.275
supply a variety of organic functionalities including γ-amino alcohols [12], β-amino acids [13], β-hydroxy ketones [14][15] and β-hydroxynitriles [14][15].
Fluorinated compounds play a central role in different branches of chemistry [16]. The incorporation of a fluorine atom into bioactive molecules
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Graphical Abstract
Figure 1:
Example of bioactive molecules bearing the 2-isoxazoline nucleus.